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The world is inhabited, ruled by demons now. The government, the food companies, everything and anyone having any power at all is one of the evil bastards from hell. The big ones being the four horsemen and the seven sins, along with Lucifer being the president. The angels are trapped in heaven or enslaved on earth, earth is in a downwards spiral, god is powerless to help.
Somewhere in the united states there is an institution, holding both women and men, children included. Everyone in this place has a singe tattoo on their back: one of the angel's sword, with wings coming out from it, which glows slightly. This is the mark of the nephilim, the possible end to the demon's rule. These Nephilim were once called Shadow Hunters, humans with the blood of Uriel running through their veins. They used to keep the world safe, hunt down demons, marking themselves up with a magical item called a Steele. Now they are kept in a locked institute, drugged up so they cannot resist.
Two of these people decide to stop taking the medicine one day, and suddenly discover that everything is not how it seems. They break out with a group of people they're close to, and fight all the higher ranked demons, saving the world.